Category: 5. Biology

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  • Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer

    Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer

    Ethical statement

    This investigator-initiated study was conducted in accordance with the principles of the Declaration of Helsinki and the International Conference on Harmonization Good Clinical Practice guidelines and was approved by the ethics…

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  • MC4-R variant confirms its association with obesity during progression from childhood to adolescence

    MC4-R variant confirms its association with obesity during progression from childhood to adolescence

    This small follow up study demonstrates that the rs12970134 variant near the melanocortin receptor 4 (MC4-R) not only explicates an obesogenic effect in the prepubertal age but remains a major risk factor also during post pubertal age. Pubertal…

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  • Algae octopus (Abdopus aculeatus) | Nature Ecology & Evolution

    Algae octopus (Abdopus aculeatus) | Nature Ecology & Evolution

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  • Re-analysis of mobile mRNA datasets raises questions about the extent of long-distance mRNA communication

    Re-analysis of mobile mRNA datasets raises questions about the extent of long-distance mRNA communication

    A key step in mobile mRNA studies is the assignment of RNA-seq reads to different genotypes. One way of identifying the genotype is based on single nucleotide polymorphisms (SNPs) (Fig. 1). Typically, a requirement is made for a defined number of…

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  • Pollution-eating microbes are thriving in infamous NYC canal

    Pollution-eating microbes are thriving in infamous NYC canal

    For more than 150 years, industrial pollution, chemical waste, and sewage have flowed into Brooklyn’s Gowanus Canal. The New York City waterway is…

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  • Biomarker-informed care for patients with renal cell carcinoma

    Biomarker-informed care for patients with renal cell carcinoma

  • Huang, J. et al. A global trend analysis of kidney cancer incidence and mortality and their associations with smoking, alcohol consumption, and metabolic syndrome. Eur. Urol. Focus 8, 200–209 (2022).

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    PubMed 

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  • Age-related blood condition counteracted with a common diabetes drug

    Age-related blood condition counteracted with a common diabetes drug

    Age-related blood condition counteracted with a common diabetes drug

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  • A modular artificial intelligence framework to facilitate fluorophore design

    A modular artificial intelligence framework to facilitate fluorophore design

    Data collection and processing

    In our previous study, a database (SMFluo1) focusing on near infrared fluorophores was constructed, containing five widely used fluorescent scaffolds29. The limitation in data volume of SMFluo1 makes it difficult to…

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