Ethical statement
This research complies with all relevant ethical regulations. All animal experiments were conducted in accordance with the protocols approved by the Institutional Animal Care and Use Committee of the Jinan University. The…
Category: 5. Biology
-
Molecular structure and enzymatic mechanism of the human collagen hydroxylysine galactosyltransferase GLT25D1/COLGALT1
GLT25D1/COLGALT1 is a Mn2+ dependent galactosyltransferase
We established methods to recombinantly produce and purify human full-length GLT25D1/COLGALT1 in E. coli and obtained enzyme preparations suitable for evaluation of galactosyltransferase…
Continue Reading
-
Structural and biochemical mechanism of short-chain enoyl-CoA hydratase (ECHS1) substrate recognition
Overall architecture of ECHS1
Mitochondrial fatty acid β-oxidation (FAO) is the primary fatty acid metabolism pathway in the human body and plays a key role in maintaining energy homeostasis in the liver, heart, and skeletal muscle26. The FAO…
Continue Reading
-
![Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair](https://scienewsd.appsfornexus.com/wp-content/uploads/2025/04/41467_2025_58361_Fig1_HTML.png)
Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair
Al-Tassan, N. et al. Inherited variants of MYH associated with somatic G: C→ T: a mutations in colorectal tumors. Nat. Genet. 30, 227–232 (2002).
Google Scholar
Raetz, A. G. &…
Continue Reading
-
Inflammatory conditions shape phenotypic and functional characteristics of lung-resident memory T cells in mice
Ethics statement
The study was approved by the Government of Lower Franconia, which nominated an external ethics committee that authorized the experiments. Studies were performed under the project license AZ 55.2.2-2532-2-1081.
Adenoviral vector…
Continue Reading
-
Neocortical tau propagation is a mediator of clinical heterogeneity in Alzheimer’s disease
Alzheimer’s Association. Alzheimer’s disease facts and figures. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring. 2022;18:700–89.
Hardy J, Duff K, Hardy KG, Perez-Tur J,…
Continue Reading
-
C12ORF49 inhibits ferroptosis in hepatocellular carcinoma cells via reprogramming SREBP1/SCD1-mediated lipid metabolism
Clinical specimens and reagents
HCC tumor and non-tumor tissues (n = 268) were acquired from patients diagnosed with hepatocellular carcinoma (HCC) at the Air Force Medical University in Xi’an, China. The tissue samples were obtained with…
Continue Reading
-
TRAPT: a multi-stage fused deep learning framework for predicting transcriptional regulators based on large-scale epigenomic data
Overview of TRAPT
TRAPT is a multi-omics framework of integration that is designed for inferring TR activity from a set of queried genes. In simple terms, the model takes interest genes as input and outputs the activity score for each TR (Fig. 1a…
Continue Reading
-
A stress-tolerant strain Rhodococcus sp. WH103 was isolated and co-immobilized to more efficiently degrade phenazine-1-carboxylic acid
Mavrodi, D. V., Blankenfeldt, W. & Thomashow, L. S. Phenazine compounds in fluorescent Pseudomonas spp. Biosynthesis and regulation. Annu. Rev. Phytopathol. 44, 417–445 (2006).
Google…
Continue Reading
-
The unusual genetic inheritance that could change Alzheimer’s treatment
Brain-tissue slides in Medellín, Colombia.Credit: Federico Rios Escobar/New York Times/Redux/eyevine
In 1982, neurologist Francisco Lopera and his colleagues at the University of Antioquia in…
Continue Reading