Origin and functional divergence of the XEG1/XLP1 gene pair in Phytophthora
To study the distribution of GH12 family proteins, we analyzed 66 oomycete species spanning multiple genera, including Albugo, Aphanomyces,…
Category: 5. Biology
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Specific selection on XEG1 and XLP1 genes correlates with host range and adaptability in Phytophthora
Origin and functional divergence of the XEG1/XLP1 gene pair in Phytophthora
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Disparate co-evolution and prevalence of sulfadoxine and pyrimethamine resistance alleles and haplotypes at dhfr and dhps genes across Africa
Whole-genome sequences from the MalariaGEN Pf7 dataset were used in this study14. Pf7 contains 8,492 QC-passed Plasmodium falciparum samples from 21 African countries which were selected for analysis. Amino acid haplotypes for dhfr and dhps were…
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Anti-amyloid could help prevent genetic form of Alzheimer’s disease
- RESEARCH HIGHLIGHT
Despite a negative primary outcome, a trial of…
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JAMMing inflammation | Nature Chemical Biology
BRCC36 is a Zn2+-dependent JAMM/MPN deubiquitinase (DUB) and is an essential component of the BRCC36 isopeptidase complex (BRISC), which blocks K63-linked ubiquitination and degradation of type I interferon receptor (IFNAR1) to enhance…
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Comparative chloroplast genomics provides insights into the phylogenetic relationships and evolutionary history for Actinidia species
Wang, F. M. et al. Evaluation of the wild Actinidia germplasm for resistance to Pseudomonas syringae pv. actinidiae. Plant Pathol. 69, 979–989 (2020).
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Pinto, D.,…
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MIRO1 mutation leads to metabolic maladaptation resulting in Parkinson’s disease-associated dopaminergic neuron loss
PD-MIRO1 mutant organoids show sustained dopaminergic neuron loss and altered astrocyte differentiation
Midbrain organoids are multi-cellular complex structures resembling the human embryonic midbrain, which are capable of recapitulating key…
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Granulosa cell transcription is similarly impacted by superovulation and aging and predicts early embryonic trajectories
Animals
All animal experiments were carried out according to governmental and institutional guidelines and approved internally by the animal welfare officer (Tierschutzbeauftragter, approval number DKFZ-366) and by the local authorities…
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Author Correction: Structural basis for the activation of plant bunyavirus replication machinery and its dual-targeted inhibition by ribavirin
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format,…
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Commensalism and pathogenesis of Candida albicans at the mucosal interface
Hube, B. Fungal adaptation to the host environment. Curr. Opin. Microbiol. 12, 347–349 (2009).
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Rokas, A. Evolution of the human pathogenic lifestyle in fungi. Nat….
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IGF2BP3/ESM1/KLF10/BECN1 positive feedback loop: a novel therapeutic target in ovarian cancer via lipid metabolism reprogramming
ESM1 silencing reduced cholesterol synthesis and promoted lipolysis in OC cells
Studies have shown that dysregulation of lipid metabolism affects the development of OC [35, 37]. Our previous work found that ESM1 was related to lipid metabolism [
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