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Sinka, M. E. et al. A new malaria vector…
Category: 5. Biology
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Cell tropism of adeno-associated viruses within the mouse inner ear in vivo: from embryonic to adult stages
Cell tropism of AAV vectors in the embryonic inner ear
Injections were performed between days 13 and 15 of embryonic development (E13 to E15). The viral preparation (1 µL) was injected directly into one of the otocysts of each embryo in the…
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USP9X integrates TGF-β and hypoxia signalings to promote ovarian cancer chemoresistance via HIF-2α-maintained stemness
USP9X is synergistically enriched with TGF-β signaling in chemoresistant HGOSC and predicts poor progression
Based on the scattered reports about TGF-β signaling involvement in ovarian cancer (OC) progression and chemoresistance, we analyzed…
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UnitedMet harnesses RNA–metabolite covariation to impute metabolite levels in clinical samples
Data preprocessing
This study complies with all relevant ethical regulations and was approved by the institutional review board at Memorial Sloan Kettering Cancer Center (MSKCC).
The input to UnitedMet consists of reference datasets with paired…
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A dynamic nomogram for predicting abdominal lymph node recurrence in patients with esophageal carcinoma
Although the standard treatment regimen for advanced TEC is neoadjuvant therapy followed by surgery, radiotherapy after surgery remains a common treatment modality in China. Previous studies had considered postoperative radiotherapy as an…
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Itaconate boosts type I IFN response by disrupting cytoprotection
Itaconate boosts type I IFN response by disrupting cytoprotection
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Improved acid-driven inhibition of effector T cell function by a pHLIP variant-conjugated PD-L1
Synthesis of PD-L1-pHLIPva
For pHLIP coupling, sulfosucclnlmldyl 4-(N-malemldomethyl) cyclohexane-1-carboxylate (sulfo-SMCC) (ThermoFisher, USA) (4800 nmol in 300 µL PBS) was added into murine PD-L1 ECD protein (prepared…
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Distinct evolutionary regimes across domains of the Plasmodium falciparum CSP gene
UNICEF & Malaria (2023). https://data.unicef.org/topic/child-health/malaria/ Accessed 23 Aug 2024.
Amambua-Ngwa, A. et al. Major subpopulations of Plasmodium falciparum in sub-Saharan Africa. Science 365, 813–816 (2019).
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Zygotic activation of transposable elements during zebrafish early embryogenesis
Zebrafish embryo collection
Two zebrafish strains, AB and India WT, were used in this study. They were reared in a pH (7.2–7.6) controlled recirculation system at around 28 °C, with a 14-h light and 10-h dark cycle. Breeding involved placing…
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Plant species as ecological engineers of microtopography in a temperate sedge-grass marsh
Larcher, W. Physiological Plant Ecology: Ecophysiology and Stress Physiology of Functional Groups (Springer, 2003).
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Crawford, R. M. M. Plants at the Margin Ecological Limits and…
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