Work in the T.V.P. laboratory is supported by the European Union’s Horizon 2020 research and innovation program Theralymph (grant agreement no. 874708), the Swiss National Science Foundation (CR32I3_166326, 310030_212387 and 310030_197878),…
Category: 5. Biology
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Therapeutic target prediction for orphan diseases integrating genome-wide and transcriptome-wide association studies
Target gene perturbation profiles
Target gene perturbation profiles arising from either gene knockdown or overexpression experiments were obtained from the L1000 database45. This database provided 978 landmark genes, called “L1000 genes.” We…
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Unravelling pollen diet and microbiome influence on honey bee health
Understanding how trophic resources affect honey bee health remains a significant knowledge gap, limiting the development of strategies to protect bees from climate change. Analysing and correlating gut microbiome composition with immune-related…
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Chemical-based epigenetic reprogramming to advance pluripotency and totipotency
Geng, T., Zhang, D. & Jiang, W. Epigenetic regulation of transition among different pluripotent states: concise review. Stem Cells 37, 1372–1380 (2019).
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Lu, F. &…
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Reporting complete chloroplast genome of endangered red mulberry, useful for understanding hybridization and phylogenetic relationships
Nepal, M. P. & Purintun, J. M. Systematics of the genus Morus L. (Moraceae): Taxonomy, phylogeny and potential responses to climate change (CRC, 2021).
Nepal, M. & Wichern, D. J. Taxonomic status of red mulberry (Morus rubra, Moraceae) at its…
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Cancer chemoprevention: signaling pathways and strategic approaches
Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 74, 229–263 (2024).
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Reply to: Byproducts in the synthesis of [68Ga]Ga-PSMA-11
Clore, J. & Scott, P. J. H. [68Ga]PSMA-11 for positron emission tomography (PET) imaging of prostate-specific membrane antigen (PSMA)-positive lesions in men with prostate cancer. Expert Rev. Mol. Diagn. 24, 565–582 (2024).
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Multiple stressors affect function rather than taxonomic structure of freshwater microbial communities
Folke, C. et al. Regime shifts, resilience, and biodiversity in ecosystem management. Annu. Rev. Ecol. Evol. Syst. 35, 557–581 (2004).
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Hector, A. & Bagchi, R. Biodiversity and…
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Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
Cloning, overexpression, and purification of S. aureus FusB and EF-G
S. aureus EF-G was purified as published18 by immobilized metal chromatography and size exclusion chromatography. The final protein sample was stored in 50 mM Tris-HCl pH 7.5,…
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A multidisciplinary approach towards modeling of a virtual human lung
Levine, S. et al. The global impact of respiratory disease. 3rd edn, European Respiratory Society. 6–7 (2021).
Cohen, M., Levine, S. M. & Zar, H. J. World Lung Day: impact of “the big 5 lung diseases” in the context of COVID-19. Am. J….
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