Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the ‘powerhouses’ of our cells, allows us to make the fuel we need from sugars, a process vital to all life on…
Category: 5. Biology
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Scientists track liquid to solid shift in brain disease proteins
An international research collaboration led by Rutgers University-New Brunswick scientists that examined microscopic blobs of protein found in human cells has discovered that some morph from an almost honey-like substance to a hard…
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Small peptides play big role in halting bacterial translation
Proteins form the structural and functional backbone of the cell, and any perturbation in their synthesis can disrupt normal cellular functions. The DNA blueprint is carefully read, transcribed, and translated into functional…
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Epithelial cell competition is promoted by signaling from immune cells
Esfahani, K. et al. A review of cancer immunotherapy: from the past, to the present, to the future. Curr. Oncol. 27, S87–S97 (2020).
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Exploration potential sepsis–ferroptosis mechanisms through the use of CETSA technology and network pharmacology
Screening of Chinese medicine monomer licochalcone D
Anti-inflammatory monomers were screened by building RAW264.7 macrophage inflammation model. Double antibody sandwich method was used to detect the level of TNFa in cell supernatant. The…
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Molecular mapping of a novel locus S68 for intrasubspecific hybrid sterility in indica-indica hybrid
Van Nguyen, N. et al. Meeting the challenges of global rice production. Paddy Water Environ. 4, 1–9 (2006).
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Zou, J. et al. Unlocking crop diversity: Enhancing variations through…
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Nickase fidelity drives EvolvR-mediated diversification in mammalian cells
EvolvR diversifies mammalian genomic loci
To test whether CRISPR-guided DNA polymerases (henceforth referred to as “EvolvR”) can diversify targeted genomic loci in human cells, we designed a modified version of the EvolvR construct we…
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Analysis of preoperative serum cytokine levels in patients with oral squamous cell carcinoma
OSCC is a highly aggressive malignancy characterized by delayed diagnosis and frequent misdiagnosis, despite its superficial location in the oral cavity. The prognosis of OSCC remains poor, highlighting the critical need for its early detection….
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Chronic adulthood exposure to bisphenol A causes behavioral changes via suppressing dopamine transporter trafficking
Tewar, S. et al. Association of bisphenol A exposure and attention-deficit/hyperactivity disorder in a national sample of U.S. Children. Environ. Res. 150, 112–118. https://doi.org/10.1016/j.envres.2016.05.040 (2016).
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Nanoparticles with curcumin and piperine modulate steroid biosynthesis in prostate cancer
Colloidal and atomic force microscopy characterization of the nanoparticles
The hydrodynamic size and size distribution of empty and loaded PLGA nanoparticles were evaluated using dynamic light scattering (DLS) analysis. The average diameters of…
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