Study population
This retrospective study have been performed in accordance with the Declaration of Helsinki. Ethical approval was obtained from the ethics committee of the First People’s Hospital of Yunnan Province, the ethics committee of…
Category: 5. Biology
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Auto-sumoylation of the yeast Ubc9 E2 SUMO-conjugating enzyme extends cellular lifespan
Gene expression pattern in ulp2Δ cells is altered after multiple generations
We recently reported that growth and cell-cycle defects in ulp2Δ cells were restored after ~500 generations (G) of continuous culture with repeated cycles of dilution…
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VIRMA promotes NSCLC progression by modifying ADAR m6A and increasing the activity of the TGF-β signaling pathway
Clinical samples and information
NSCLC samples preserved in formalin and embedded in paraffin were obtained from the Second People’s Hospital of Changzhou City. All patients provided informed consent to join the study following the guidelines of…
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Correlation between pan immune inflammation value and testosterone deficiency risk increase
Tauchen, J., Jurášek, M., Huml, L. & Rimpelová, S. Medicinal use of testosterone and related steroids revisited. Molecules. 26 (4), 1032 (2021).
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Exploring the impact of R-loops on genome integrity and disease
This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it. These three-stranded nucleic acid structures, composed of an RNA:DNA hybrid and…
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Florida’s Dolphins Are Dying – Why?
A phytoplankton bloom harmed marine habitats, reduced the availability of nutritious prey for bottlenose dolphins, and caused a significant increase in strandings and deaths. In 2013, 8 percent of the bottlenose dolphins living in Florida’s…
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Beyond CRISPR: Scientists Develop New Tool for Cutting DNA
An INRS research team has identified a new family of enzymes that can make precise cuts in single-stranded DNA. A few years ago, the introduction of CRISPR technology marked a significant breakthrough in the scientific community. Derived from a…
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Taking Alcohol and Cannabis Together May Fuel More Drinking
People who use cannabis while drinking perceive fewer negative effects from alcohol consumption, potentially leading to alcohol use disorder, alcohol-related harms, and drunk driving. The corresponding study…
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Unlocking the genetic basis of adaptive evolution: study reveals complex chromosomal rearrangements in a stick insect
Understanding the material basis of adaptive evolution has been a central goal in biology dating back to at least the time of Darwin. One focus of current debates is whether adaptive evolution relies on many mutations with small and roughly equal…
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Chromosomal rearrangements drive color evolution in stick insects
Understanding the material basis of adaptive evolution has been a central goal in biology dating back to at least the time of Darwin. One focus of current debates is whether adaptive evolution relies on many mutations with small and…
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