Animals
Male C57BL/6 J mice (8–10 weeks old) obtained from Vital River Laboratory (Beijing, China) were used in all experiments. The mice were maintained under standard laboratory conditions (temperature: 23 ± 1 °C, humidity: 50%) with…
Category: 5. Biology
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Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis-splicing of autism-risk genes
Mouse models
All relevant ethical regulations for animal testing and research were observed. This study received approval from the University of Florida Institutional Animal Care and Use Committee (IACUC). All animal procedures and endpoints were…
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Linking bacterial androgen production and prostate cancer
Kenny, D. J. et al. Cell Host Microbe 28, 245–257.e6 (2020).
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Yao, L. et al. Nat. Microbiol. 7, 1404–1418 (2022).
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Electron transfer engineering of artificially designed cell factory for complete biosynthesis of steroids
DHCR7 is rate-limiting step for complete biosynthesis of Cho in S. cerevisiae
First, we constructed the biosynthetic pathway to produce 7-dehydrocholesterol (Dhc), the key precursor of Cho. Considering the endogenous…
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LncRNA NEAT1 sponges miR-214-3p to promote osteoblast differentiation through regulating the PI3K/AKT/mTOR pathway in aortic valve calcification
Ethics statements
The study protocol was approved by the Ethical Committee of the Affiliated Hospital of Qingdao University (QYFY WZLL 28950), and informed consents were obtained from all the participants. All experiments were performed in…
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Leveraging vision transformers and entropy-based attention for accurate micro-expression recognition
Experimental methodology
Our experiments aim to assess the effectiveness of the key components of our framework: the LAPE module, the ESAAT module, and the diffusion model-based data augmentation technique. We also compare our model’s…
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Differential changes in the microglial transcriptome between neonatal and adult mice after spinal cord injury
Bradbury, E. J. & Burnside, E. R. Moving beyond the glial Scar for spinal cord repair. Nat. Commun. 10 (1). https://doi.org/10.1038/s41467-019-11707-7 (2019).
Xiao, S. et al. The Syvn1 inhibits neuronal cell ferroptosis by activating Stat3/Gpx4…
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Biochar-mediated remediation of nickel and copper improved nutrient availability and physiological performance of dill plants
Kriti Kumari, B. et al. Enhancement in Ni–Cd phytoremediation efficiency of Helianthus annuus L. from battery waste contaminated soil by bacterial augmentation, isolated from e-waste contaminated sites. Int. J. Environ. Res. 17, 18.
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Phospholipase D6 activates Wnt/β-catenin signaling through mitochondrial metabolic reprogramming to promote tumorigenesis in colorectal cancer
PLD6 is upregulated and associated with poor prognosis in CRC
To explore the role of PLD6 in cancer, we first analyzed its differential expression across various cancer types using TIMER2.0. The PLD6 expression was significantly elevated in…
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Gene programs driving cortical neuron specifications
Gene programs driving cortical neuron specifications
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