Category: 5. Biology

The lysosomal protease cathepsin B is actively removed from human cells during Coxiella burnetii infection

To globally assess host protease abundance during C. burnetii infection, we performed label-free mass spectrometry on lysates from…

Cryo-EM structures of C. crescentus CpaF

Tad pilus extension and retraction in C. crescentus is a rapid and highly dynamic process driven by the ATPase activity of CpaF²². This enzyme is predicted to adopt a quadripartite domain architecture,…

Type-I TA systems are abundant in bacterial genomes, and their toxin counterparts have been shown to exert potent killing effects when overexpressed²³. The toxins therefore constitute interesting starting points for development of unique…

X-ray imaging is a widely used technique in medical, industrial, and scientific fields. However, conventional X-ray imaging relies on the difference in attenuating power of the sample when X-rays pass through it, which gives limited contrast in…

Cell lines

CRC cell lines HCT116 (RRID: CVCL_0291) and SW480 (RRID: CVCL_0546) were purchased from the American Type Culture Collection (ATCC). LS174T cells were kindly provided by Dr. Ragnhild A. Lothe (Oslo University Hospital, Norway). SW837…