The synthesis and secretion of melatonin from the pineal gland are primarily regulated by the external light/dark cycle via the central circadian clock located in the suprachiasmatic nuclei of the hypothalamus1. Melatonin levels typically peak at…
Category: 5. Biology
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Preclinical validation of TGFβ inhibitors as a novel therapeutic strategy for post-traumatic heterotopic ossification
TGFβ inhibitors selectively regulate SMAD2/3 phosphorylation while having minor effects on the proliferation and survival of human primary MPCs
We and others have previously demonstrated that TGFβ levels are elevated in humans after injury and…
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Pan-cancer analysis reveals immunological and prognostic significance of CCT5 in human tumors
Expression level
We initially employed TIMER2.0, to analyze the expression levels of CCT5. As shown in Fig. 2A, the expression level of CCT5 was significantly higher in tumor cells than in the corresponding normal tissues, including BLCA, BRCA,…
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Linking vector favourable environmental conditions with serological evidence of widespread bluetongue virus exposure in livestock in Ecuador
The results reveal widespread evidence of BTV exposure, geographically matching favourable vector ecosystems within a temperature range of 12–32 °C. We explored the dependency of bioclimatic variables on natural regions and the distribution…
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In vivo and in vitro spermatogenesis in prepubertal mouse testes exposed to low gonadotoxic doses of cytarabine or Daunorubicin
Wasilewski-Masker, K. et al. Male infertility in long-term survivors of pediatric cancer: a report from the childhood cancer survivor study. J. Cancer Surviv Res. Pract. 8, 437–447 (2014).
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Androgen receptor activation for breast cancer therapy
Breast cancer overwhelmingly affects women (approximately 1000:1 ratio of women to men), with around 80% of cases driven by oncogenic oestrogen receptor-α (ERα) activity. Endocrine therapy, including surgical removal of ovaries (oophorectomy),…
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Tumor organoid-immune co-culture models: exploring a new perspective of tumor immunity
Valkenburg KC, de Groot AE, Pienta KJ. Targeting the tumour stroma to improve cancer therapy. Nat Rev Clin Oncol 2018;15:366–81.
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Yang S, Hu H, Kung…
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A multifunctional nursing pad for lactating mothers
Water holding capacity
A Water holding capacity (WHC) test was carried out to measure absorbency, as it directly measures liquid retention. It evaluates the fabric’s ability to retain water within its structure, expressed as a percentage of its…
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Astaxanthin alleviates fipronil-induced neuronal damages in male rats through modulating oxidative stress, apoptosis, and inflammatory markers
Richardson, J. R., Fitsanakis, V., Westerink, R. H. S. & Kanthasamy, A. G. Neurotoxicity of pesticides. Acta Neuropathol. 138, 343–362 (2019).
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Platelet-rich plasma and IL-1β antagonist receptor peptide attenuate the inflammatory process of muscle injury in wistar rats
The excessive and prolonged inflammatory response can delay regeneration, damage muscle fibers, and consequently form muscle fibrosis25,26. One of the processes responsible for amplifying this response is the translocation of NF-kB to the…
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