Antibiotic resistance is a serious threat to public health. When antibiotics don’t work, we risk not being able to treat many types of infections and people who would previously have been cured, can die.
One example is the…
Category: 5. Biology
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New Study Shows How a Rare Genetic Error Disrupts Brain Development in Autism
Scientists found a genetic link between autism and DM1, where repeat DNA sequences disrupt brain gene splicing. This sheds light on ASD’s development and opens new paths for targeted treatments. Researchers from The Hospital for Sick Children…
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Tumor organoid-immune co-culture models: exploring a new perspective of tumor immunity
Valkenburg KC, de Groot AE, Pienta KJ. Targeting the tumour stroma to improve cancer therapy. Nat Rev Clin Oncol 2018;15:366–81.
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Yang S, Hu H, Kung…
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A multifunctional nursing pad for lactating mothers
Water holding capacity
A Water holding capacity (WHC) test was carried out to measure absorbency, as it directly measures liquid retention. It evaluates the fabric’s ability to retain water within its structure, expressed as a percentage of its…
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Astaxanthin alleviates fipronil-induced neuronal damages in male rats through modulating oxidative stress, apoptosis, and inflammatory markers
Richardson, J. R., Fitsanakis, V., Westerink, R. H. S. & Kanthasamy, A. G. Neurotoxicity of pesticides. Acta Neuropathol. 138, 343–362 (2019).
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Platelet-rich plasma and IL-1β antagonist receptor peptide attenuate the inflammatory process of muscle injury in wistar rats
The excessive and prolonged inflammatory response can delay regeneration, damage muscle fibers, and consequently form muscle fibrosis25,26. One of the processes responsible for amplifying this response is the translocation of NF-kB to the…
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Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success
The lysosomal protease cathepsin B is actively removed from human cells during Coxiella burnetii infection
To globally assess host protease abundance during C. burnetii infection, we performed label-free mass spectrometry on lysates from…
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Conformational changes in the motor ATPase CpaF facilitate a rotary mechanism of Tad pilus assembly
Cryo-EM structures of C. crescentus CpaF
Tad pilus extension and retraction in C. crescentus is a rapid and highly dynamic process driven by the ATPase activity of CpaF22. This enzyme is predicted to adopt a quadripartite domain architecture,…
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Rational design of synthetic antimicrobial peptides based on the Escherichia coli ShoB toxin
Type-I TA systems are abundant in bacterial genomes, and their toxin counterparts have been shown to exert potent killing effects when overexpressed23. The toxins therefore constitute interesting starting points for development of unique…
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Quantifying grating defects in X-ray Talbot-Lau interferometry through a comparative study of two fabrication techniques
X-ray imaging is a widely used technique in medical, industrial, and scientific fields. However, conventional X-ray imaging relies on the difference in attenuating power of the sample when X-rays pass through it, which gives limited contrast in…
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