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Chen, H. et al. PPAR-gamma…
Category: 5. Biology
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AKT1 as a therapeutic target for platinum-resistant SOX2 positive ovarian cancer cells
Ovarian tumor tissue microarray
Ovarian tumor and adjacent normal tissues were collected from 58 patients admitted to Fengxian Central Hospital Affiliated to the Southern Medical University (Shanghai, China) for surgical resection between January…
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Alternate Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation
Grainyhead O-isoforms maintain ISCs by preventing differentiation
We examined two grh amorphic (null) alleles, grhS2140 and grhIM, in addition to a hypomorphic allele, grh370 which only disrupts collective O-isoform function (both Grh.RJ and…
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Inflammation, toxicity, and apoptosis reducing potential of bacteriophage Ariobarzanes on intestinal cells infected with Salmonella Typhimurium
Preparation of bacterial strains and phage solution
Salmonella enterica serovar Typhimurium ATCC 14,028 was obtained from the Department of Food Hygiene at the Faculty of Veterinary Medicine of Shiraz University (Iran). S. Typhimurium was cultured…
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Correlation study of PBK/TOPK expression, prognosis, and immune infiltration in breast cancer
Bioinformatics analysis results
PBK/TOPK mRNA expression and its relationship with clinicopathologic features
To evaluate PBK/TOPK mRNA expression across cancers, RNA sequencing data from TCGA were obtained via the TIMER database. The results…
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Maximum lifespan and brain size in mammals are associated with gene family size expansion related to immune system functions
Stearns, S. C. The Evolution of Life Histories249 (Oxford University Press, 1992).
Tidière, M. et al. Comparative analyses of longevity and senescence reveal variable survival benefits of living in zoos across mammals. Sci. Rep. 6, 1–7 (2016).
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Humans learn generalizable representations through efficient coding
Ethics statement
Participants gave informed consent. The experimental protocol was approved by the University Committee on Activities involving Human Subjects at Rensselaer Polytechnic Institute (IRB-2055). Our experiment did not collect any…
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NR2F2 regulation of interstitial cell fate in the embryonic mouse testis and its impact on differences of sex development
Characterizing the interstitial cell populations of embryonic testis using single-nucleus multiomics
To characterize the testicular cellular composition, and in particular, to gain insight into the poorly characterized interstitial cell diversity…
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USP22 enhances atherosclerotic plaque stability and macrophage efferocytosis by stabilizing PPARγ
Wang, W. et al. Global Burden of Disease Study 2019 suggests that metabolic risk factors are the leading drivers of the burden of ischemic heart disease. Cell Metab. 33, 1943–1956.e2 (2021).
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Analysis of the significance and gender differences in the factors influencing antisocial behaviors among adolescents
Study participants
This study used stratified and random sampling methods to conduct a cross-sectional survey. Thirty high schools (15 rural high schools and 15 urban high schools) were randomly selected from 16 prefecture-level cities in Shandong…
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