Selection of the optimal host for heterologous expression of T2PKs
Through a comparative analysis of the functional characteristics across distinct organism hosts, we prioritized Streptomyces hosts as the initial focus for chassis development due…
Category: 5. Biology
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SWIFT-seq enables comprehensive single-cell transcriptomic profiling of circulating tumor cells in multiple myeloma and its precursors
Kyle, R. A. et al. Clinical course and prognosis of smoldering (asymptomatic) multiple myeloma. N. Engl. J. Med. 356, 2582–2590 (2007).
Kyle, R. A. et al. A long-term study of prognosis in…
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A second photoactivatable state of the anion-conducting channelrhodopsin GtACR1 empowers persistent activity
GtACR1 variant Q46E
To gain insights into the functional differences between CrChR2 and GtACR1, we compared the existing X-ray structures57,58 of the central constriction sites, which represent the functional cores of…
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Long-range enhancers rely on LHX motifs
In mammals, some enhancers are capable of regulating target genes that are located a megabase away. However, the DNA sequences or chromatin features that permit this long-range activity are still elusive. In a truly remarkable study, Evgeny Kvon…
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Entorhinal cortex layer III Adgrl2 expression controls topographical circuit connectivity required for sequence learning
Topographically positioned MEC neurons have distinct axonal projection patterns
In addition to the Adgrl2 topographical expression profile that is observed in the MEC, Adgrl2 expression is confined to select neurons in superficial II/III layers [
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Oversized nanodiscs for combined structural and functional investigation of multicomponent membrane protein systems
Fagerberg, L., Jonasson, K., von Heijne, G., Uhlén, M. & Berglund, L. Prediction of the human membrane proteome. Proteomics 10, 1141–1149 (2010).
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Overington, J. P.,…
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Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting
Study participants and sampling
Mother–child pairs during the first year of life
Mother–child pairs from an urban clinic, The Gambia, participating in a trial of maternal immunization with MenAfriVAC were included (NCT03746665). All samples…
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Author Correction: Multiscale dynamic immunomodulation by a nanoemulsified Trojan-TLR7/8 adjuvant for robust protection against heterologous pandemic and endemic viruses
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate…
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Impact of climate change on the distribution of Ligustrum leucanthum using MaxEnt modeling
Kufa, C. A., Bekele, A. & Atickem, A. Impacts of climate change on predicted habitat suitability and distribution of Djaffa mountains Guereza (Colobus guereza gallarum, Neumann 1902) using MaxEnt algorithm in eastern Ethiopian highland. Glob….
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Turning gene expression up and down
CRISPR-based technologies facilitate genome manipulation to understand the function of specific elements and have even entered the clinic to treat disease via modulation of gene expression. Existing approaches to screen regulatory effects in the…
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