Curation of the quality-controlled whole-genome knockout collection
The QC collection was built by removing redundancy from an earlier condensed collection (CC) of G. oxydans transposon mutants and supplementing with additional mutants from a…
Category: 5. Biology
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Genome sequencing of a novel Verticillium dahliae strain (huangweibingjun)
Morphological and evolutionary analysis of Huangweibingjun
Naturally infected root samples of cotton plants exhibiting wilting symptoms were collected from the field, surface-sterilized, inoculated on potato dextrose agar (PDA), and incubated in…
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Molecular dynamics simulation and docking studies reveals inhibition of NF-kB signaling as a promising therapeutic drug target for reduction in cytokines storms
Yang, L. et al. The signal pathways and treatment of cytokine storm in COVID-19. Signal. Transd. Target. Ther. 6, 1–20 (2021).
Antin, J. H. & Ferrara, J. L. M. Cytokine dysregulation and…
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Modelling the species-area relationship using extreme value theory
Extreme value theory
Let Fi(r) be the cumulative distribution function (cdf) of the distances, Ri, of individuals of a species i to a focal point. Then, the cdf of the corresponding minimum, Li(r), for a sample of n individuals is simply the…
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Single-cell transcriptomics reveal how root tissues adapt to soil stress
Plant materials and growth conditions
The rice line used in this study is Xkitaake, a Kitaake line transformed with the XA21 gene driven by the maize (Zea mays) ubiquitin promoter15,34. To ensure that the presence of XA21 does not influence the…
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Epitope-optimized vaccine elicits enduring immunity against swine influenza A virus
Coates, B. M., Staricha, K. L., Wiese, K. M. & Ridge, K. M. Influenza A Virus Infection, Innate Immunity, and Childhood. JAMA Pediatr. 169, 956–963 (2015).
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Antibiotic residues correlate with antibiotic resistance of Salmonella typhimurium isolated from edible chicken meat
The widespread use of antibiotics in poultry farms either for therapeutic purposes or to promote growth have been recognized as a major threat to public health1,2. The negative consequences of antibiotic abuse include changes in the resistance…
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An organoid library unveils subtype-specific IGF-1 dependency via a YAP–AP1 axis in human small cell lung cancer
Dingemans, A.-M. C. et al. Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 32, 839–853 (2021).
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Rudin,…
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Inhibition of MBTPS1 enhances antitumor immunity and potentiates anti-PD-1 immunotherapy
Ethical statement
All patient samples used in the present study were obtained from the Sun Yat-sen University Cancer Center (SYSUCC) in Guangzhou, China. Prior to sample collection, written informed consent was obtained from each participant,…
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Network-based clustering unveils interconnected landscapes of genomic and clinical features across myeloid malignancies
Analysis Overview
Figure 1 provides an illustration of our clustering methodology, where genomic and clinical data are integrated in networks of their probabilistic relationships. This method allows us to delineate cluster-specific probabilistic…
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