Current treatments for Parkinson’s disease (PD) are focused on symptom management, but these often lose efficacy over time and can cause side effects. Cell therapies aimed at replacing lost dopaminergic neurons are being explored, but clinical…
Category: 5. Biology
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FAERS based disproportionality analysis and network pharmacology investigation of taxanes associated drug induced liver injury
Nižnanský, Ľ. et al. Natural taxanes: from plant composition to human Pharmacology and toxicity. Int. J. Mol. Sci. 23, 15619 (2022).
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Louage,…
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Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures
Tzioras, M., McGeachan, R. I., Durrant, C. S. & Spires-Jones, T. L. Synaptic degeneration in Alzheimer disease. Nat. Rev. Neurol. 19, 19–38 (2023).
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Knopman, D. S….
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The novel compound PICCS improves cell viability during cold storage and reduces pulmonary ischemia-reperfusion injury in a rat model
Synthesis of TY52156 and other compounds
TY52156 was synthesized according to a previously described method24. Various compounds were synthesized using TY52156 as a seed compound at the Center for Innovation in Immunoregulatory Technology and…
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A cytosolic glyoxylate shunt complements the canonical photorespiratory pathway in Arabidopsis
Loss of/reduced function of glyoxylate reductase 1 partially rescues the growth and metabolic phenotypes of the hpr1 mutant
To identify proteins with a regulatory or modulatory role in photorespiration, we performed ethyl methanesulfonate (EMS)…
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A deeper dive into primitive polylactate polymerization and microdroplet assembly under restrictive early Earth conditions
Chandru K, Potiszil C, Jia TZ. Alternative pathways in astrobiology: Reviewing and synthesizing contingency and non-biomolecular origins of terrestrial and extraterrestrial life. Life. 2024;14:1069.
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Intranasal delivery of drugs to the central nervous system of adult zebrafish
Kalueff, A. V., Stewart, A. M. & Gerlai, R. Zebrafish as an emerging model for studying complex brain disorders. Trends Pharmacol. Sci. 35, 63–75 (2014).
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The genetic basis of a colorful signal: the polymorphic dewlap of the slender anole (Anolis apletophallus)
Abramoff MD, Magalhaes PJ, Ram SJ (2004) Image processing with ImageJ. Bioph Int 11(7):36–42
Alföldi J, di Palma F, Grabherr M, Williams C, Kong L, Mauceli E et al. (2011) The genome of the…
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Transcriptome associated with single-cell analysis reveal the role of S-palmitoylation in coronary artery disease
Data collection and standardization
The training set (GSE113079), validation set (GSE23561), and single-cell dataset (GSE121893) originated from The Gene Expression Omnibus (GEO) database (https://ww.ncbinlm.nih.gov/geo/). The GSE113079 dataset…
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KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging
Animal procedures
C57BL/6J HccRsd mice were purchased from Envigo or generated at the Centro de Biología Molecular Severo Ochoa (Madrid, Spain) animal facilities. All mice required for this study were bred and aged in specific-pathogen-free…
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