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Category: 5. Biology
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A DNA-gated molecular guard controls bacterial Hailong anti-phage defence
Animal and bacterial cells use nucleotidyltransferase (NTase) enzymes to respond to viral infection and control major forms of immune signaling including cGAS-STING innate immunity and CBASS anti-phage defence1-4. Here we discover a family of…
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β-Catenin interacts with canonical RBPs including MSI2 to associate with a Wnt signalling mRNA network in myeloid leukaemia cells
Nusse R, Clevers H. Wnt/beta-catenin signaling, disease, and emerging therapeutic modalities. Cell. 2017;169:985–99. https://doi.org/10.1016/j.cell.2017.05.016.
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PDGFRα signaling regulates cartilage and fibrous tissue differentiation during synovial joint development
Pdgfra expression in the developing limb bud and knee joint
Recent studies have explored murine joint development through single-cell RNA sequencing (scRNA-seq), but Pdgfra has not been a focus13,36,37. scRNA-seq of the…
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GōMartini 3: From large conformational changes in proteins to environmental bias corrections
The Martini 3 Protein Model
The Martini 3 protein model is the natural evolution of the previous Martini 2 iteration29, which now leverages the improvements introduced with the Martini 3 force field. However, it can still be considered as a…
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IgA clears gut viruses | Nature Immunology
Secretory IgA coats the intestinal microbiota and is the most abundant antibody isotype produced in the mammalian gastrointestinal mucosa. In Cell Host and Microbe, Lisicka et al. show that IgA prevents chronic gut colonization by viruses and…
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Characteristics of leaf nutrient resorption efficiency in Tibetan alpine permafrost ecosystems
Study area
This study was conducted across the permafrost region of the Tibetan Plateau (Fig. 1b). The plateau is the world’s largest area of alpine permafrost in the low to middle latitudes (~1.1 × 106 km2) with an average elevation of…
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CDK4/6-mediated phosphorylation of DUB3 promotes YAP1 stability and hepatocellular carcinoma progression
Singal AG, Kanwal F, Llovet JM. Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy. Nat Rev Clin Oncol. 2023;20:864–84.
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Skin–gut crosstalk | Nature Immunology
Skin damage can have systemic effects but whether it can result in the priming of immune responses that are spatially removed from the skin is less clear. Data now published in Science Immunology show that cytokines released from damaged skin can…
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Direct genome-scale screening of Gluconobacter oxydans B58 for rare earth element bioleaching
Curation of the quality-controlled whole-genome knockout collection
The QC collection was built by removing redundancy from an earlier condensed collection (CC) of G. oxydans transposon mutants and supplementing with additional mutants from a…
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