Category: 5. Biology

Ethical declaration

Ethical approval for the use of peripheral blood samples from human donors was granted by the Swedish Ethical Review Authority (registration number 2018/1498-31/3). All human studies were carried out in accordance with the…

HINT2 expression is decreased in patients and mice with MASLD and cellular models of MASLD

By analyzing Gene Expression Omnibus datasets, we found that hepatic HINT2 expression was significantly lower in patients with MASLD than in control…

Mouse strains

Mice were housed under a 12-h light/dark cycle at 21 ± 1 °C with 40–70% humidity at the Technical University of Munich, Institute of Pharmacology and Toxicology. BL6 Xist^−/+ females were purchased from Riken BRC Japan…

All the animal studies comply with all relevant ethical regulations. All the in vivo PK/PD and efficacy animal studies were performed under University of Michigan IACUC approval of animal protocols: PRO00009463 and PRO00011174 (P.I. Shaomeng…

Single addition of GFs requires much higher concentration for the same effect

GFs are inherently unstable proteins, with some of them having half-lives below 1 h in solution at 37°C¹². Myokines, which are also known to induce muscle hypertrophy

Low concentrations of CBD did not induce cell death in A539 cells

CBD has been shown to exhibit anticancer activity and influence apoptotic cell death at high doses (above 40 μM)^9,14. This study aimed to investigate the potential of CBD to…

We identified 63,826 viral scaffolds from 10 hydrothermal plumes, 40 hydrothermal vent deposits, and 2 diffuse flow metagenomes (Supplementary Data 1). Following viral identification, we conducted viral genome binning to reconstruct 5708 vMAGs….