CHMP5 enables transcription of the T-ALL gene program
To elucidate CHMP5 function in T-ALL pathogenesis, we used short hairpins RNA (shRNA) to “knock-down” (KD) CHMP5 (Supplementary Fig. 1a) in CUTLL1 cells, a CD4+CD8+ human T-ALL caused by a…
Category: 5. Biology
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Extramedullary disease but not paraskeletal disease portends inferior outcomes after CAR T cell therapy in multiple myeloma
Munshi NC, Anderson LD Jr, Shah N, Madduri D, Berdeja J, Lonial S, et al. Idecabtagene vicleucel in relapsed and refractory multiple myeloma. N Engl J Med. 2021;384:705–16.
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Interpretable machine learning model for predicting post-hepatectomy liver failure in hepatocellular carcinoma
In this study, we successfully developed a personalized prediction model utilizing the ML algorithm to assess the risk of PHLF in HCC patients. Firstly, we applied LASSO and RF-RFE to screen out 12 critical variables,…
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Coastal oceanographic connectivity at the global scale: a dataset of pairwise probabilities and travel times derived from biophysical modeling
Manel, S., Boulanger, E., Benestan, L., Mouillot, D. & Dalongeville, A. Revisiting long-distance dispersal in a coastal marine fish. Ecography 2023 (2023).
Gouvêa, L. P. et al. Oceanographic connectivity explains the intra-specific diversity of…
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Liposomal lipid nanoparticles for extrahepatic delivery of mRNA
All animal protocols were approved by the Canadian Animal Care Committee and conducted in accordance with relevant University of British Columbia guidelines and regulations (A22-0044, A20-0132).
Materials
All ionizable lipid used in this study…
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Acoustic behaviour and flight tone frequency changes in adult Aedes albopictus and Culex quinquefasciatus mosquitoes
Drosopoulos, S. & Claridge, M. F. Insect Sounds and Communication: Physiology, Behaviour, Ecology, and Evolution. (1st ed.). CRC Press. https://doi.org/10.1201/9781420039337 (2005)
Johnston, C. Original communications: Auditory apparatus of the…
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Harnessing the FGFR2/NF2/YAP signaling-dependent necroptosis to develop an FGFR2/IL-8 dual blockade therapeutic strategy
Ethics
All animal experiments received approval from Peking University Cancer Hospital’s Institutional Animal Care and Use Committee (Approval NO. EAEC 2020–08), with rigorous efforts made to minimize animal suffering.
In vivo animal…
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Huntingtin inclusion bodies have distinct immunophenotypes and ubiquitination profiles in the Huntington’s disease human cerebral cortex
Martin, J. B. & Gusella, J. F. Huntington’s disease. Pathogenesis and management. N. Engl. J. Med. 315 (20), 1267–1276 (1986).
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MacDonald, M. E. et al. A…
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Genome-wide analysis of the BoBZR1 family genes and transcriptome analysis in Brassica oleracea
Zhang, P. et al. Genome-wide identification and functional characterization of wheat Brassinazole-resistant transcription factors in response to abiotic stresses and Stripe rust infection. Front. Plant Sci. 14, 1144379 (2023).
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On the utility of immobilized phenylarsine oxide in the study of redox sensitive cardiac proteins
Batty, M., Bennett, M. R. & Yu, E. The role of oxidative stress in atherosclerosis. Cells 11(23). (2022).
Cadenas, S. ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection. Free Radic Biol. Med. 117, 76–89…
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