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Anaclet, C. & Fuller,…
Category: 5. Biology
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Understanding the logic and grammar of cis-regulatory elements
Cis-regulatory elements (CREs), such as promoters and enhancers, possess complex architectures of transcription factors that determine specific expression patterns, levels and responses to diverse cellular or environmental cues. Understanding the…
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Extended culture of 2D gastruloids to model human mesoderm development
Arnold, S. J. & Robertson, E. J. Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo. Nat. Rev. Mol. Cell Biol. 10, 91–103 (2009).
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The mechanism of miR-155 targeting PIK3R1 in the pathogenesis of preeclampsia
Clinical sample
All placental samples were obtained from preeclamptic (PE) patients and normal controls at Jinhua People’s Hospital, following ethical approval from the hospital’s Ethics Committee (Approval No. IRB-2020063-R). The PE patient…
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Activation of lysosomal iron triggers ferroptosis in cancer
Ethics
Fresh tumour samples were obtained by surgery from patients at Paul Brousse and Institut Curie care centres. All patients provided written informed consent for use of tumour samples. The study was approved by institutional regulatory boards…
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A chimeric viral platform for directed evolution in mammalian cells
Cell culture
BHK-21 [C-13] cells (#CCL-10) were sourced from the American Type Culture Collection (ATCC). Wildtype and CRISPR/Cas9-modified BHK-21 cells were maintained in a humidified 37 °C (5% CO2) atmosphere in MEM α (ThermoFisher,…
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Body mass index and benign prostatic hyperplasia correlate with urinary microbiome diversity and lower urinary tract symptoms in men
Clinical characteristics of study participants
We utilized urine samples and phenotypic data from 500 men at baseline as part of the MrOS study20,25. These 500 men were randomly selected from the overall cohort of 5994 MrOS participants. The…
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Potential shared neoantigens from pan-cancer transcript isoforms
Impact of the dataset choice on pan-cancer-specific isoform detection
The goal of this study is to identify common instances of transcript isoform switching across 41 cancer cohorts from three cancer databases, TCGA28, PCAWG33, and the Oncobox…
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Working memory filtering at encoding and maintenance in healthy ageing, Alzheimer’s and Parkinson’s disease
Nobre, A. C., Stokes, M. G. & Premembering Experience A hierarchy of Time-Scales for proactive attention. Neuron https://doi.org/10.1016/j.neuron.2019.08.030 (2019).
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