Initial sample cohort selection and rationale in glioma cohort A
There were two primary objectives in sample selection. The first was to conduct a comparative analysis of different glioma types, aiming to characterize the inherent variability…
Category: 5. Biology
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Augmenting precision medicine via targeted RNA-Seq detection of expressed mutations
In this study, four targeted panels were used to assess variant detection in paired targeted DNA-seq and RNA-seq data generated for the reference samples (Fig. 1). These panels (the Agilent Clear-seq Custom Comprehensive Cancer DNA panels…
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An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission
Ethics statement and mice
All experiments were performed in accordance with GV-SOLAS and FELASA guidelines and have been approved by German authorities (Regierungspräsidium Karlsruhe), or according to the guidelines defined by the Home Office and…
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H2A.Z is essential for oocyte maturation and fertility in female mouse
Schultz, R. M., Stein, P. & Svoboda, P. The oocyte-to-embryo transition in mouse: past, present, and future. Biol. Reprod. 99, 160–174 (2018).
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A checklist for designing and improving the visualization of scientific data
I thank my colleagues T. Weissgerber, A. Gucek, S. Royle and J. P. Saenz for feedback on the draft version of this Comment, as well as the many students of my data-viz courses, whose examples continually expand my expertise and whose requests for…
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H2A.Z reinforces maternal H3K4me3 formation and is essential for meiotic progression in mouse oocytes
Clift, D. & Schuh, M. Restarting life: fertilization and the transition from meiosis to mitosis. Nat. Rev. Mol. Cell Biol. 14, 549–562 (2013).
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FedOcw: optimized federated learning for cross-lingual speech-based Parkinson’s disease detection
To evaluate the effectiveness of our proposed federated learning framework for speech-based Parkinson’s disease detection, we utilized five multilingual datasets, incorporating Spanish, Italian, Chinese, Czech, and English speech samples. These…
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Establishing predictive machine learning models for drug responses in patient derived cell culture
To develop an efficient methodology for predicting drug responses in patient-derived cell lines we performed a few initial probing experiments using a dedicated validation set from the GDSC1 dataset (Fig. 2). These provided the foundation for…
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High-throughput multiplex voltage-clamp/current-clamp evaluation of acutely isolated neurons
Hamill, O. P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F. J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391, 85–100 (1981).
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The brain works at more than 10 bits per second
A recent article makes a claim with far-reaching implications for neuroscience, technology, and society: that the human brain is subject to an information processing ‘speed limit’ of 10 bits per second. Although this speed limit appears to…
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