A collaborative team from Penn Medicine and Penn Engineering has uncovered the mathematical principles behind a 500-million-year-old protein network that determines whether foreign materials are recognized as friend or foe. How does your body…
Category: 5. Biology
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Scientists Crack the 500-Million-Year-Old Code That Controls Your Immune System
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Formation of tiny living bots can reset the cellular aging clock
Modern humans have existed for over 200,000 years, and each new generation has begun with a single cell-dividing, changing shape and function, organizing into tissues, organs, and limbs. With slight variations, the process has…
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Study reveals intercellular flow as crucial factor in tissue mechanics
Water makes up around 60 percent of the human body. More than half of this water sloshes around inside the cells that make up organs and tissues. Much of the remaining water flows in the nooks and crannies between cells, much like…
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Breakthrough study maps hidden protein dynamics in cancer cells
A team of international researchers led by scientists at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States, with its National Medical Center named a Top 5 “Best…
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Gravity, flipped: How tiny, porous particles sink faster in ocean snowstorms
The deep ocean can often look like a real-life snow globe. As organic particles from plant and animal matter on the surface sink downward, they combine with dust and other material to create “marine snow,” a beautiful display of ocean weather…
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Profiling crRNA architectures for enhanced Cas12 biosensing
Optimizing conditions to saturate cas12-crRNA complex formation and DNA binding
Cas12 trans-cleavage activity is dependent upon the formation of a ternary complex: Cas12 assembles with crRNA, and the ribonucleoprotein-complex binds to target DNA,…
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Cell-type specific reductions in interneuron gene expression within the cingulate gyrus of schizophrenia and bipolar disorder subjects
Rolls, E. T. The cingulate cortex and limbic systems for action, emotion, and memory. Handb. Clin. Neurol. 166, 23–37 (2019).
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Vogt, B. A. The cingulate cortex in…
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Advance and Prospect of Positron Emission Tomography in Alzheimer’s disease research
Petersen RC. Mild cognitive impairment: transition between aging and Alzheimer’s disease. Neurologia. 2000;15.
Portet F, Ousset PJ, Visser PJ, Frisoni GB, Nobili F, Scheltens P, et al. Mild cognitive impairment (MCI) in medical practice: a critical…
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Improved gut microbiota by selenium-enriched Bifidobacterium longum DD98 alleviates chemotherapy-induced intestinal mucositis via inhibiting the STING pathway
Regents and chemical
The origin of the B. longum DD98 strain and fermentation procedure of SeDD98 were described previously46. In brief, the DD98 strain was selected using a high-throughput screening approach and was enriched by applying it in…
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Pr and Pfr structures of plant phytochrome A
Pr structures
We present 1.58 and 1.86 Å cryogenic MX structures derived from single crystals of PCB and PФB adducts (PDB codes 8R44 and 8R45, Fig. 1 and Supplementary Fig. 3, respectively; more detailed electron density and omit maps are…
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