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Category: 5. Biology
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Ancient marine reptile was a silent swimmer
Ancient marine reptile was a silent swimmer
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PANCS-Binders: a rapid, high-throughput binder discovery platform
Cloning and bacterial strain handling
All plasmids and phage (Supplementary Table 1) were cloned by Gibson Assembly of PCR fragments generated using Q5 DNA polymerase (NEB). All primers (Supplementary Table 2) were ordered from IDT. Three E. coli…
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Publisher Correction: NINJ1 regulates plasma membrane fragility under mechanical strain
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format,…
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Assessing the implications of habitat transformations on human-large carnivore interactions outside protected areas
Frank, B., Glikman, J. A. & Marchini, S. Human–Wildlife Interactions: Turning Conflict into Coexistence – Google Books. Cambridge University Press vol. 23 (2019).
Nyhus, P. J. Human-Wildlife conflict and coexistence. Annu. Rev. Environ. Resour.…
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Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states
Regev, A. et al. The human cell atlas. eLife 6, e27041 (2017).
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Karlsson, M. et al. A single-cell type transcriptomics map of human tissues. Sci. Adv. 7,…
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Membrane-domain compartmentalization of active GPCRs by β-arrestins through PtdIns(4,5)P2 binding
Reagents and plasmids
AVP and isoproterenol (ISO) were purchased from Sigma-Aldrich. Tetramethylrhodamine (TMR)-labeled HiBiT peptide (TMR–HiBiT: TMR-VSGWRLFKKIS) was synthesized in Genscript. SaraFluor650-labeled Flag–HiBiT23 (SF650–FiBiT:…
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Potassium binding by carbonyl clusters, halophilic adaptation and catalysis of Haloferax mediterranei D-2-hydroxyacid dehydrogenase
Domain closure of D2HDH on substrate binding
The structure of the non-productive ternary complex of D2HDH with both oxidised NADP+ and 2-ketohexanoic acid was determined at 1.26 Å resolution, using crystals grown from protein prepared in 1 M…
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Identification of new selective CD36 inhibitors to potentiate HER2-targeted therapy in HER2-positive breast cancer
In silico analysis to identify new CD36 inhibitors
To identify new CD36 inhibitors, we screened in silico a commercial library of 30,000 compounds (https://www.hit2lead.com) targeting a protein region around the FA binding site centered at Val142…
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Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1
Human tissue samples
De-identified human specimens were collected from the Autopsy Service in the Department of Pathology at the University of California San Francisco (UCSF) (Supplementary Table 2) with previous patient consent in strict…
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