Wistar scientists have combined a promising cancer therapy with a molecule that targets tumors to treat cancer more effectively. The new approach could be a way to deliver treatment directly to tumors at higher doses, while reducing…
Category: 5. Biology
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Gut bacteria use formic acid as an electron taxi
Researchers at Goethe University Frankfurt have discovered a surprising role for formic acid in the human gut: The small molecule acts as a kind of “taxi” for electrons – both within bacteria and, likely, also between…
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Water pressure mechanism enables fast amoeboid cancer cell movement
Cancer is one of the leading causes of death worldwide, marked by the uncontrolled growth of abnormal cells. What makes it more dangerous is the ability of cancer cells to move quickly through the body, allowing them to invade…
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A role for condensin-mediator interaction in mitotic chromosome organization
Koshland, D. & Strunnikov, A. Mitotic chromosome condensation. Annu. Rev. Cell Dev. Biol. 12, 305–333 (1996).
Hirano, T. Chromosome cohesion, condensation, and separation. Annu. Rev. Biochem…
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Integrating multi-omics analysis identifies DNA damage-related gene CLSPN as a biomarker in gastric cancer
Sundar, R. et al. Gastric cancer. Lancet 405(10494), 2087–2102 (2025).
Qiu, H. et al. Cancer incidence, mortality, and burden in china: a time-trend analysis and comparison with the united States and united Kingdom based on the global…
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Computational identification of multi-target natural compounds from Sesbania grandiflora as potential therapeutic agents against Klebsiella pneumoniae
Ashurst John, V. & Dawson Adam. Klebsiella Pneumonia [Updated 2023 Jul 20]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing https://www.ncbi.nlm.nih.gov/books/NBK519004/
Guo, Y. et al. Oral pathobiont Klebsiella chaperon usher…
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STYK1 expression in breast cancer and its association with vascular invasion and clinicopathological features
Storr, S. J. et al. Calpastatin is associated with lymphovascular invasion in breast cancer. Breast 20, 413–418. https://doi.org/10.1016/j.breast.2011.04.002 (2011).
Robinson, D. R., Wu, Y….
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Early-life stress impairs development of functional interactions and neuronal activity within prefrontal-amygdala networks in vivo
ELS does not affect the development of local oscillatory network activity in mPFC or BLAa
To test the effect of ELS on the development of prefrontal-amygdala networks, male and female pups were exposed to the ELS LBN paradigm between P4-14 with…
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Electrostatic properties of disordered regions control transcription factor search and pioneer activity
Biggin, M. D. Animal transcription networks as highly connected, quantitative continua. Dev. Cell 21, 611–626 (2011).
Strebinger, D. et al. Endogenous fluctuations of OCT4 and SOX2 bias…
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Scaled up fed-batch production of recombinant alpha-1-antitrypsin by CHO cells in single-use surface aerated orbital shaken bioreactor
Connolly, B. et al. SERPINA1 mRNA as a treatment for alpha-1 antitrypsin deficiency. J. Nucl. Acids 2018, 7 (2018).
Kelly, E. et al. Alpha-1 antitrypsin deficiency. Respir. Med. 104(6),…
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