CLL transcriptome data
For all considered CLL datasets (Table S3, refs.â38,39,40), we first performed gene expression filtering using statistical distribution fitting and threshold-based filtering (Fig. S1, Methods)14,41. From the whole…
Category: 5. Biology
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Conservation of dark CPD photolyase function in blind cavefish
Fish maintenance and dissection of tissues
Wild type (iCab) and photolyase mutant medaka (Oryzias latipes) were maintained in the fish facility of the Institute of Biological and Chemical Systems, Biological Information Processing (IBCS-BIP) at…
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Computationally unmasking each fatty acyl C=C position in complex lipids by routine LC-MS/MS lipidomics
Cell culture
The murine RAW264.7 cell line was obtained from the American Type Culture Collection (ATCC #TIB-71). RAW264.7 cells were cultured as described elsewhere14 in complete DMEM (containing 1% v/v P/S, 10% v/v FBS, and 1% v/v glutamine) in…
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Frozen in Time: The Hidden Trick That Keeps Human Eggs Alive for Decades
Human eggs can remain viable for decades by dialing down their internal recycling systems, new research shows. Studying over 100 freshly donated eggs, scientists discovered that slowing protein breakdown helps minimize harmful byproducts that…
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Three orphaned groundhogs released back into the wild
Three rescued groundhog (Marmota monax) siblings were joyfully released back…
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Microglia are prominent producers of inflammatory cytokines during the hyperacute phase of ischemic stroke
DiSabato, D. J., Quan, N. & Godbout, J. P. Neuroinflammation: the devil is in the details. J. Neurochem 139, 136â153 (2016).
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Gauberti, M. et al….
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Genome-wide CRISPR screen for human factors involved in alternative polyadenylation based on differential localization of CD47
CD47 mRNA 3â˛âUTR length affects its protein localization
Previous studies have demonstrated that global alterations in mRNA polyadenylation, resulting from the utilization of different PASs, play a crucial role in post-transcriptional gene…
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Diabetic retinopathy classification using a multi-attention residual refinement architecture
This section focuses on the method of the proposed model. We first introduced the class-specific residual attention module and then proposed a multi-attention mechanism to improve the ability of small object detection (lesions detection). Then,…
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Identification of the AKR gene family in sweet cherry and its response to different abiotic stresses
Phylogenetic analysis of the cherry AKR family genes
To explore the evolutionary relationships of PaAKR gene family, a phylogenetic tree of 60 genes from cherry and Arabidopsis was constructed using MEGA7.0, which was divided into 4 subfamilies…
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Quality Evaluation Based Simulation Selection (QEBSS) for analysis of conformational ensembles and dynamics of multidomain proteins
Vogel, C., Bashton, M., Kerrison, N. D., Chothia, C. & Teichmann, S. A. Structure, function and evolution of multidomain proteins. Curr. Opin. Struct. Biol. 14, 208â16 (2004).
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