Category: 5. Biology

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  • Evidential deep learning-based drug-target interaction prediction

    Evidential deep learning-based drug-target interaction prediction

    Datasets

    Three datasets DrugBank68, Davis59, and KIBA60 were used for model evaluation. Supplementary Table 1 summarizes these datasets.

    DrugBank: the data used in this study were published on January 3, 2020 (version 5.1.5). Drugs with inorganic…

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  • Inoculation with Talaromyces trachyspermus and arbuscular mycorrhizal fungus alongside sulfonylurea herbicides alters Orobanche aegyptiaca and tomato growth

    Inoculation with Talaromyces trachyspermus and arbuscular mycorrhizal fungus alongside sulfonylurea herbicides alters Orobanche aegyptiaca and tomato growth

    The mycorrhizal colonization rate was found to be significantly influenced by fungi and herbicides (P ≤ 0.01). However, the application methods of the herbicides were not effective in the greenhouse experiment. In plants that were not…

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  • Identification and validation of biomarkers associated with glycolysis in polycystic ovarian syndrome

    Identification and validation of biomarkers associated with glycolysis in polycystic ovarian syndrome

  • Boyle, J. A. & Teede, H. J. PCOS: refining diagnostic features in PCOS to optimize health outcomes. Nat. Reviews Endocrinol. 12 (11), 630–631 (2016).

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  • Li, J. et al. Effect of exposure to…

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  • A complex between IF2 and NusA suggests early coupling of transcription-translation

    A complex between IF2 and NusA suggests early coupling of transcription-translation

    Labeling of IFs and fMet-tRNAfMet

    To fluorescence label the IFs for live-cell single-molecule tracking, we explored if the addition of a HaloTag compromises IF activity in supporting cell growth (Supplementary Note 1)….

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  • Longitudinal transcriptomic and epigenetic analysis of the blood in two astronauts

    Longitudinal transcriptomic and epigenetic analysis of the blood in two astronauts

    Whole blood transcriptomics

    Two participants provided three blood samples each (Fig. 1A). The blood samples were collected at the pre-flight mark (T0, within two weeks before departure), at post-flight (T2, within 24 hours after landing), and at…

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  • Removal of E. coli O157:H7 coliform bacteria from sewage wastewater using silver doped borate bioglass

    Removal of E. coli O157:H7 coliform bacteria from sewage wastewater using silver doped borate bioglass

    Preparation of BAgX BG samples

    Five types of silver-doped borate BG samples, BAg0, BAg1, BAg2, BAg3, and BAg4, were prepared by the melt-quenching method at high temperatures between 1100 and 1200 °C as spherical-shaped discs (Fig. 2). After the…

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  • A genetically encoded biosensor for point-of-care and live-cell detection of d-2-hydroxyglutarate

    A genetically encoded biosensor for point-of-care and live-cell detection of d-2-hydroxyglutarate

    Ethical statement

    All procedures were performed in compliance with relevant laws and institutional guidelines. Animal studies were approved by the Second Hospital of Shandong University Ethics Committees (Approval No. KYLL-2022A128). Human…

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  • In vivo efficacy of NRL knockdown with cell-penetrating siRNA in retinal degeneration

    In vivo efficacy of NRL knockdown with cell-penetrating siRNA in retinal degeneration

    Design and synthesis of cp-asiNRL

    Sequences targeting NRL were designed for homology with Homo sapiens, Rattus norvegicus, and Mus musculus. Sequence information is provided in Supplementary Table 1. Knockdown efficacies were validated in HeLa…

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  • Effects of abiotic and biotic elicitors on tomato resistance to tomato brown rugose fruit virus

    Effects of abiotic and biotic elicitors on tomato resistance to tomato brown rugose fruit virus

    Sources and Preparation of bacterial and viral isolates

    The bacterium P. fluorescens 1442 (P) was obtained from the bacterial collection at the Agricultural Sciences and Natural Resources University of Khuzestan (Mollasani, Iran), and the…

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