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Category: 5. Biology
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Rare germline variant in NFATC4 associated with familial CLL
Rare germline variant in NFATC4 associated with familial CLL
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Association of pulse pressure with presynaptic dysfunction in older adults with Alzheimer’s disease: a cohort study
Our findings revealed significant relationships between PP and the presynaptic dysfunction marker CSF GAP-43, and CSF p-tau levels. Mediation analysis further suggested that CSF GAP-43 may serve as potential pathway through which vascular aging…
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Development and validation of a visual nomogram for predicting clinically significant prostate cancer in negative mpMRI using 68Ga-PSMA PET/CT
The use of mpMRI has increased for the localization of newly diagnosed lesions and repeat biopsies due to its sensitivity in detecting csPCa17. For positive mpMRI, systematic biopsy plus target biopsy can improve the detection of csPCa. For…
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Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst
Exogenous FGF is sufficient to drive human hypoblast specification
We hypothesized that FGF4 may play a conserved role in human pre-implantation development. Transcriptional analysis of human pre-implantation embryos17,18,19 indicates that there…
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LAMP5 modulates IRF4 stability and nuclear transport: a critical mechanism in myeloma progression and therapy
LAMP5 is critical for myeloma disease progression
By utilizing the Broad Institute Cancer Cell Line Encyclopedia (CCLE) database, our analysis indicated that LAMP5 exhibits the highest expression in myeloma cells among numerous types of tumors and…
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![Computational studies on structural aspects of pyrazolo[3,4-b]pyridine derivatives as TRKA inhibitors in cancer therapy](https://scienewsd.appsfornexus.com/wp-content/uploads/2025/07/41598_2025_8370_Fig1_HTML.jpg)
Computational studies on structural aspects of pyrazolo[3,4-b]pyridine derivatives as TRKA inhibitors in cancer therapy
Pharmacophore hypothesis dataset and validation of the pharmacophore model
A total of 19 hypotheses were generated in this model, each demonstrating interactions with the identified receptor molecules. Each hypothesis is assigned a specific value,…
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Development of tetraculture spheroids as a versatile 3D model for personalized breast cancer research
Cell culture
T47D, BT474, SK-BR-3, MDA-MB-231, Ea.Hy926, THP-1 cell lines were purchased from ATCC. T47D and BT474 were cultured in RPMI-1640 (Merck Millipore Corporation, Germany) medium with 10% fetal bovine serum (FBS) and 1%…
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YAP–TAZ overactivation promotes glomerular epithelial proliferative disease
Epithelial proliferation is a key driver of glomerular injury in conditions such as collapsing glomerulopathy or crescentic glomerulonephritis. Two new studies, one led by Darren Yuen and the other by Pierre Isnard and Fabiola Terzi, highlight…
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Single-quantum sodium MRI at 3 T for separation of mono- and bi-T2 sodium signals
Theoretical development
Model of sodium MRI signals
We use a two-population model, Eq. (1), to describe the single-quantum sodium image signal, m(t), evolving with time t at an imaging voxel ∆V. Time t = 0 is at the center of excitation RF…
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