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Murphy, M. P. & LeVine, H. 3rd…
Category: 5. Biology
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Liquid-liquid phase separation of ZHX2 protects DLBCL cells against ferroptosis through induction of SLC3A2
ZHX2 is overexpressed in DLBCL and promotes DLBCL proliferation
To clarify the characteristics of ZHX2 in DLBCL, immunohistochemistry (IHC) showed elevated expression in DLBCL (n = 60) compared to normal tonsils (n = 30; mean optical density…
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SOuLMuSiC, a novel tool for predicting the impact of mutations on protein solubility
Prediction performances
We tested the prediction performance of SOuLMuSiC on different datasets. We started with the training set \(\mathcal {D}_{Sol}\), and evaluated the performance in leave-one-out cross-validation at protein level. The…
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A network analysis of carbapenem-resistant Klebsiella pneumoniae among healthcare facilities
Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the United States, 2019. Atlanta, GA: U.S. Department of Health and Human Services (2019).
Hayden, M. K. et al. Prevention of colonization and infection by Klebsiella…
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The transcription factor WRKY25 can act as redox switch to drive the expression of WRKY53 during leaf senescence in arabidopsis
Transactivation potential with the WRKY53/WRKY25/WRKY18 subnetwork
To gain further insight into the potential regulatory subnetwork formed by WRKY18, WRKY25, and WRKY53, we studied the interactions among these three WRKYs and their effects on each…
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A fungal effector promotes infection via stabilizing a negative regulatory factor of chloroplast immunity
Plant materials and growth conditions
Nicotiana benthamiana wild-type and gene silencing lines, Phaseolus vulgaris, Solanum lycopersicum, and soybean wild-type (Glycine max cv. Williams 82) and the Gmmorf2a/b mutants were maintained at 22 °C in…
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Effects of neoadjuvant immunotherapy on hearing in patients with head and neck squamous cell carcinoma
Study design and patients
We conducted a single-site, institutional chart review to identify adults who had received ICB and also underwent audiologic assessments within 1 month prior to ICB treatment initiation and after receiving ICB treatment….
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Unlocking the African bioeconomy and strengthening biodiversity conservation through genomics and bioinformatics
Ebenezer, T. E. et al. Africa: sequence 100,000 species to safeguard biodiversity. Nature 603, 388–392 (2022).
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Sharaf, A. et al. Bridging the gap in African biodiversity genomics…
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A single mutation may contribute to accelerated evolution of SARS-CoV-2 toward Omicron
Wang, X., Lu, L. & Jiang, S. SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences. Trends immunol. 45, 81–84 (2024).
Kimura, I. et al. Virological characteristics…
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TLRs are blind to pseudouridine RNA
The recognition of RNA by TLR7 and TLR8 is important for pathogen defense. Pseudouridine (Ψ)-containing RNA is found in endogenous RNA and is used in mRNA vaccines because it lacks immunostimulatory activity. In Cell, Bérouti et al. identify…
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