Auffarth, B. Generative AI with LangChain: Build Large Language Model (LLM) Apps with Python, ChatGPT, and other LLMs (Packt Publishing, 2023).
Sahoo, P. et al. A systematic survey of prompt engineering in large language models: Techniques and…
Category: 5. Biology
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Polyphasic characterization and mating type allele distribution of Monilinia laxa in Iranian stone fruit orchards
Sample collection and fungus isolation
Samples were collected from infected trees with typical brown rot disease symptoms from the spring of 2018 to the summer of 2022. At the journey’s end, 565 samples were collected with the permission of the…
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Quantifying coral reef–ocean interactions is critical for predicting reef futures under climate change
Quantifying coral reef–ocean interactions is critical for predicting reef futures under climate change
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Unique metabolic regulation of micromeres contributes to gastrulation in the sea urchin embryo
Micromeres have a unique metabolic profile
To test if micromeres have distinct metabolic properties, we performed metabolomics for micromeres and non-micromeres at the 16-cell stage of sea urchin (Strongylocentrotus purpuratus; Sp) embryos, using…
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Structural insights into Type II-D Cas9 and its robust cleavage activity
NsCas9d cleaves target DNA with minimal 20-nt complementarity
To explore the diversity of Cas9 proteins, we selected 162 orthologs to construct a phylogenetic tree. The Type II-D Cas9s formed a distinct clade, showing a closer evolutionary…
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Emerging uses of artificial intelligence in deep time biodiversity research
Raup, D. M. & Sepkoski, J. J. Mass extinctions in the marine fossil record. N. Ser. 215, 1501–1503 (1982).
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Benton, M. J. Recovery of vertebrate faunas from the end-Permian mass…
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Towards a quality control framework for cerebral cortical organoids
The stochastic nature of the differentiation of stem cells and their spontaneous self-organization within cerebral organoids leads to unpredictable variability among them1. Consequently, novel approaches have recently emerged to improve culture…
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Effect of substrate mineralogy, biofilm and extracellular polymeric substances on bacterially induced carbonate mineralisation investigated with in situ nanoscale ToF-SIMS
Dubey, A. A., Dhami, N. K., Ravi, K. & Mukherjee, A. Erosion mitigation with biocementation: a review on applications, challenges, & future perspectives. Rev. Environ. Sci. Bio/Technology. https://doi.org/10.1007/s11157-023-09674-z (2023).
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Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues
Ethics statement
All animal experiments were approved by Institutional Animal Care and Use Committee (IACUC) of Peking University, which are accredited by the AAALAC (Association for Assessment and Accreditation of Laboratory Animal Care…
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Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex
APJR-βarr1 complexes with distinct stoichiometry
To promote the assembly of a functional complex, we followed an established protocol for GPCR-βarr1 structural determination24. Briefly, the C-terminal segment (residues C331-D380) of the APJR was…
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