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  • Impact of work instruction difficulty on cognitive load and operational efficiency

    Impact of work instruction difficulty on cognitive load and operational efficiency

    Subjective data analyses

    In this subsection, we analyze the subjective data collected from participants during the three sessions of the experiment. We utilized two questionnaires, the NASA_TLX and the short version of the DSSQ. These…

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  • Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis

    Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis

    Ethics

    The study adhered to all applicable regulations governing the use of human participants and was conducted in accordance with the principles of the Declaration of Helsinki. Participants in the FinnGen study provided informed consent for…

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  • Successful birth after preimplantation genetic testing for rare mitochondrial DNA mutation m.10197G>A

    Successful birth after preimplantation genetic testing for rare mitochondrial DNA mutation m.10197G>A

    Mitochondrial DNA (mtDNA) disorders are usually heteroplasmic, with cells harboring both wild-type and mutated mtDNA. They may become apparent once the number of affected mitochondria reaches a certain level. The threshold varies from tissue to…

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  • PGC-1α mediates migrasome secretion accelerating macrophage–myofibroblast transition and contributing to sepsis-associated pulmonary fibrosis

    PGC-1α mediates migrasome secretion accelerating macrophage–myofibroblast transition and contributing to sepsis-associated pulmonary fibrosis

    MMT involved in LPS-induced pulmonary fibrosis

    SAPF mouse models were established as shown in Supplementary Fig. 1a. Pulmonary injury and collagen deposition were assessed using H&E and Masson staining, showing significant interstitial leukocyte…

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  • Object detection model design for tiny road surface damage

    Object detection model design for tiny road surface damage

    Figure 1 illustrates the general structure of the RSDD, which consists of a backbone, a neck, and a detection head. Among them, the backbone is enhanced by dual scale convolutional downsampling module (DSCD), multi-strategy feature extraction…

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  • Generation and characterization of neutralizing antibodies against M1R and B6R proteins of monkeypox virus

    Generation and characterization of neutralizing antibodies against M1R and B6R proteins of monkeypox virus

    Isolation and characterization of antibodies targeting MPXV M1R and B6R

    In this study, we employed phage surface display technology to identify a diverse and extensive array of antibodies targeting M1R and B6R proteins on the surface of MPXV…

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  • Mathematical modelling and sliding characteristics analysis on the spherical movable teeth for the toroidal drive

    Mathematical modelling and sliding characteristics analysis on the spherical movable teeth for the toroidal drive

    To study the kinematics of spherical movable teeth, a Frenet-coordinate system is affixed to the path of the movable tooth centre. As shown in Fig. 2, three sets of coordinate systems are introduced. The first coordinate system (world),…

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  • MSK1 promotes colorectal cancer metastasis by increasing Snail protein stability through USP5-mediated Snail deubiquitination

    MSK1 promotes colorectal cancer metastasis by increasing Snail protein stability through USP5-mediated Snail deubiquitination

    Cell culture

    All cell lines used in this study were obtained from the Korean Cell Line Bank, where they were characterized by DNA fingerprinting and isozyme detection and cultured according to American Type Culture Collection instructions. All…

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  • Emergent Haldane model and photon-valley locking in chiral cavities

    Emergent Haldane model and photon-valley locking in chiral cavities

  • Hofstadter, D. R. Energy levels and wave functions of Bloch electrons in rational and irrational magnetic fields. Phys. Rev. B 14, 2239–2249 (1976).

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  • Haldane, F. D. M….

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