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  • Mitochondrial, metabolic and bioenergetic adaptations drive plasticity of colorectal cancer cells and shape their chemosensitivity

    Mitochondrial, metabolic and bioenergetic adaptations drive plasticity of colorectal cancer cells and shape their chemosensitivity

    A subgroup of CRC cells displays drastically reduced mitochondrial biomass

    CRC exhibit remarkable heterogeneity dividing them into four molecular subtypes (CMS1-4), which are additionally characterized by features such as microsatellite…

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  • Improved post-transplant outcomes for elderly acute myeloid leukemia patients conditioned with FLU/BU4 rather than conventional MAC regimens

    Improved post-transplant outcomes for elderly acute myeloid leukemia patients conditioned with FLU/BU4 rather than conventional MAC regimens

    Characteristics of patients and transplants

    A total of 6551 AML patients who underwent allogenic HSCT with MAC regimens were extracted from the Japanese nationwide registry. Among them, 905 patients received FLU/BU4, while 5646 patients received…

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