The dynamic alterations of fifteen BAs at different stages of chronic liver diseases associated with HBV infection
A cohort of 267 patients with chronic HBV infection was prospectively enrolled, comprising 117 CHB, 47 HBV-CHC, 49 HBV-DHC, and 54…
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Nfe2l1 dysfunction alters Parkinson’s disease-related gene expression and impairs neuronal differentiation under ubiquitin stress in neuronal differentiated P19 Cells
Cell culture and neuronal differentiation
P19 embryonal carcinoma cells were cultured in Maintenance Medium (DMEM High Glucose w/ L-Glutamine w/ Sodium Pyruvate supplemented with 10% FBS, 100 units/mL penicillin and 100 units/mL streptomycin), and…
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Pre-saccadic Attention (and not Arousal) modulates the Size-Eccentricity Effect
To estimate the SEEs obtained when participants prepared a saccade to a target appearing near or at the location of the peripheral test object, pressed a key, or maintained fixation, we computed psychometric function parameters. Figure 2 shows…
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A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia
Human study participants
Affected individual 1 and parents of affected individuals 2, 3 and 4, and of fetus 5 provided their written consent for genetic testing, analysis of fibroblasts and publication of images. The study was performed according…
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A student academic performance prediction model based on the interval belief rule base
In this section, two case studies were used to verify the validity and superiority of the IBRB-C student performance prediction model. In Subsection “IBRB-C model for prediction of graduate admission success rate”, a graduate application…
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Time’s arrow
Forget all the nonsense you heard about time travel. You can’t go back and kill your grandfather. The past has already happened. Everything is linked, each event underpins the next, everything is determined; you can’t do anything to break…
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A novel bacterial protein family that catalyses nitrous oxide reduction
Tian, H. et al. Global nitrous oxide budget (1980–2020). Earth Syst. Sci. Data 16, 2543–2604 (2024).
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Sanford, R. A. et al. Unexpected nondenitrifier nitrous oxide reductase gene…
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Near dipole-dipole interaction induced control of high-precision three-dimensional atom localization via probe absorption in a four-level phase-coherent atomic medium
The field-coupled energy-level configuration of our four-level scheme is shown in Fig. 1a, where the dipole allowed transitions \({|{1}\rangle }\)–\({|{2}\rangle }\), \({|{2}\rangle }\)–\({|{3}\rangle }\) and \({|{2}\rangle }\)–\({|{4}\rangle…
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Azimuthal anisotropy induced by partial flux-closure in self-assembled tubular permalloy membranes
Sample design and self-assembly of tubular structures
The fabrication of planar NiFe structures on a shapeable polymeric platform enables their self-assembly into three-dimensional tubular architectures. This platform consists of…
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