A naturally selected αβ T cell receptor binds HLA-DQ2 molecules without co-contacting the presented peptide

Discovery of a peptide independent CD4⁺ T cell restricted to HLA-DQ2.5

Using tetramer based magnetic enrichment^10,11 and single cell index sorting approaches, we isolated CD4⁺ T cells binding to HLA-DQ2.5 (DQA1*05:01/DQB1*02:01) tetramers…