To comprehensively evaluate the sequence selectivity of DNMT3 enzymes, we constructed eight enzyme–DNA complex models based on the available crystal structures: DNMT3A bound to CGC, CGT, CGA, CGG, and DNMT3B bound to CGG, CGT, CGA, CGC. In…
So close yet so far apart: distinct flanking sequence recognition by DNMT3A and DNMT3B
