An unexpected tumor-resistant phenotype from floxing PAK1 in a mouse model of colitis associated cancer

PAK1 is overexpressed in human IBD and CRC^5,11,12and we have previously shown that total Pak1 deletion in a mouse model of IBD reduces tumor multiplicity upon AOM/DSS treatment⁷. However, in IL10KO mice, another mouse model of IBD, Pak1 deletion…