Cystobactamid off-target profiling reveals favorable safety, superoxide reduction, and SCARB1 inhibition in eukaryotes

CYS demonstrates general safety in cytotoxicity and genotoxicity assays, with a mild effect on uncoupling the mitochondrial electron transfer chain (ETC)

Three CYS derivatives (CN-861-2, CN-DM-861 and Cysto-180; Fig. 1a) were chosen to further…

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