The antibody-peptide fusion protein, AT-02, is an effective opsonin with pan-amyloid reactivity

Antibody production and purification

A humanized IgG1κ VH9/VL4 monoclonal antibody (mAb) was generated from the murine 11-1F4 antibody^19,20,28,59 by homology modeling and backmutation (Genscript, NJ). Nucleotide sequences encoding a spacer and a…