UCP2 inhibition eliminates pancreatic β cell autoinflammation in T2DM with islet-mitochondrial sequential targeting nanomedicines

STING was significantly activated in β cells of T2DM patients

First, we compared the islet RNA sequencing data of 18 non-diabetic subjects and 39 T2DM patients collected from the Gene Expression Omnibus (GEO) database. The median mRNA level of…