An improved synthesis of TRβ-selective thyromimetic GC-1

4-Benzyloxy-3-isopropyl-benzaldehyde (6)

A mixture of 4-hydoxy-3-iso- propyl benzaldehyde (64.5 g, 393.3 mmol), potassium carbonate (108.6 g, 786.9 mmol) and benzyl bromide (74.1 g, 433.3 mmol) in 800 mL of acetone was heated to reflux for…