Keratin-72 restricts HIV-1 infection in resting CD4+ T cells by sequestering capsids in intermediate filaments

KRT72 is a partner of Vpx_rcm that is specifically expressed in resting CD4⁺ T cells

As Vpx_rcm and Vpx_mnd-2 overcome a SAMHD1-independent block to improve HIV-1 RT in early-phase HIV-1 replication in resting CD4⁺ T cells²¹, the objective was to…