Molecular basis of the functional conflict between chloroquine and peptide transport in the Malaria parasite chloroquine resistance transporter PfCRT

Chloroquine’s access to the cavity recapitulates expected PfCRT isoform relationships

The CQ-sensitive wild-type (3D7) parasites are unable to evade the toxic effects of CQ because 3D7-PfCRT is unable to transport the drug in sufficient amounts…

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