Rapid and high-throughput analysis of 5-hydroxymethylfurfural in honey by MALDI-MS with in-situ tetra (4-aminophenyl)-porphyrin derivatization

General principle of TAPP-based in-situ derivatization

For MALDI MS, the direct detection of small molecules remains a challenge²⁹. This is primarily due to low desorption/ionization efficiency and interference from matrix-related signals, as…