In Silico and in vitro evaluation of the anticancer effect of a 1,5-Benzodiazepin-2-One derivative (3b) revealing potent dual inhibition of HER2 and HDAC1

Synthesis of 3b

The synthesis of 3b was carried out according to the following scheme (1) as previously reported in the previous study⁴⁴. Briefly, 3b was obtained by reacting 4,5-dimethyl-o-phenylenediamine with ethyl…