Development and validation of an LC–MS/MS method for quantitative determination of LXT-101 sustained-release suspension, a novel drug in treating prostate cancer, in beagle plasma

Chemical reagent

LXT-101 (purity: 95%, LOT: 050503) and ¹²⁷I-LXT-101 (IS, purity: ≥ 99%, LOT: 050307) were obtained from Beijing Institute of Pharmacology and Toxicology (Beijing, China). Methanol, acetonitrile and formic acid, which were of…