Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex

APJR-βarr1 complexes with distinct stoichiometry

To promote the assembly of a functional complex, we followed an established protocol for GPCR-βarr1 structural determination²⁴. Briefly, the C-terminal segment (residues C331-D380) of the APJR was…