Potassium binding by carbonyl clusters, halophilic adaptation and catalysis of Haloferax mediterranei D-2-hydroxyacid dehydrogenase

Domain closure of D2HDH on substrate binding

The structure of the non-productive ternary complex of D2HDH with both oxidised NADP+ and 2-ketohexanoic acid was determined at 1.26 Å resolution, using crystals grown from protein prepared in 1 M…

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