Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function

MGA271, 376.96, and TE9 scFv CAR-T cells mediate divergent responses against in vivo models of solid tumors

MGA271²³, 376.98²⁴, and TE9²⁵ scFv’s were cloned into a CD8-28ζ second-generation CAR format containing a CD8α hinge-transmembrane, and…