Core–shell nanofibers for localized melanoma therapy delivering Pioglitazone nanoemulsions and gemcitabine dual loaded system

Materials

PCL (Mw = 70–90 KDa), medium molecular weight chitosan (M_w = 190–310 KDa), PVA (M_w = 70–80 KDa), Tween 80, Oleic acid, Sodium alginate and DAPI (4,6-diamidino-2-phenylindole) were obtained from Sigma – Aldrich (USA). 99% Formic…